GAMP 5 · FDA CSA · 21 CFR Part 11 · EU Annex 11 · FDA AI Guidance

Computer System Validation, rebuilt for the AI era.

EVOLV drafts your requirements, test scripts, and traceability in minutes — then independently verifies every output against the GAMP 5 corpus. Every signature stays human. Every decision is inspectable by an auditor.

or explore the live platform yourself →
90+adversarial test scenarios, continuously run
Every stepcites its regulation — 21 CFR 11, Annex 11, ICH Q9
100%of signatures human — enforced, not promised
GAMP 5 Rev 221 CFR Part 11EU GMP Annex 11 ICH Q9FDA CSA GuidanceNIST AI RMFALCOA+
The problem

Validation is the tax you pay on every system — and it's still done by hand.

Months

of consultant authoring

URS, FRs, risk assessments, OQ scripts, traceability matrices — written manually, per system, per change, per site.

Drift

between docs and reality

The day validation closes, the documents start aging. Change requests pile up and nobody knows what's still in a validated state.

One

bad finding is all it takes

Generic AI tools can't survive an inspection. If the auditor can't re-derive the reasoning, the output is a liability, not an asset.

Live · runs in your browser

Screen your AI use case in 30 seconds.

Describe how you want to use AI in your GxP environment. This runs the same five hard-exclusion rules our Bounded Autonomy Profile engine applies — deterministic, no data leaves this page.

Deterministic rules · nothing is sent to a server
⛔ BAP-X — OUT OF ENVELOPE

This isn't a "needs more controls" verdict — it's a shape problem. No tier of paperwork rescues it. The good news: most excluded use cases have a nearby re-scoped shape that works (AI proposes, human signs). We'll show you that path.

✓ NO STRUCTURAL EXCLUSION

Your use case clears the five hard-exclusion rules.

Now the interesting question — which assurance tier does it need? Pick the closest description:

Get the full signed BAP assessment → Signed PDF · tier-graduated control catalogue · fragility markers
The platform

One lifecycle. AI drafts the left arm. Humans sign every gate.

EVOLV runs the full GAMP 5 V-model as a living system — from a one-paragraph brief to a signed Validation Summary Report, with a traceability matrix that updates itself as tests run and changes land.

Plan templates + frameworks Requirements AI drafts UR / FR Risk deterministic matrix Design test bundles + citations Verify execution + ALCOA+ Release signed VSR Monitor AI change impact Retire controlled exit
Paste a one-paragraph brief → AI-drafted requirements with regulatory citations → risk-adaptive test scripts → executed runs with defect capture → signed, inspection-ready PDFs. The traceability matrix stays live the whole way.
AI drafts, human signs Human executes, AI assists
Built for

Three people have to say yes. EVOLV answers each one.

QA Head / CSV Manager

"Will this survive my next inspection?"

Every AI output is independently verified, hash-chained, and signed by your people. The Logic Archive lets an inspector replay any decision. You stay the signatory — EVOLV just removes the authoring grind.

VP Regulatory Affairs

"Which frameworks does it actually track?"

GAMP 5 Rev 2, 21 CFR Part 11, EU Annex 11, ICH Q9, FDA CSA — cited per requirement and per test step, with version detection when guidance changes underneath you.

CTO / CDO

"How do I govern AI in GxP at all?"

The Bounded Autonomy Profile gives every AI deployment a tier, a control catalogue, and hard exclusions. It's the governance framework your AI strategy is missing — validation is where it starts.

Why auditors accept it

Bounded autonomy, not blind trust.

Most AI tools ask your QA team to trust a black box. EVOLV is built so nobody has to trust anything — every claim below is verifiable in the product.

🛂

Agent Passports

Every AI agent carries a machine-readable permission envelope: allowed actions, forbidden actions, data classifications, and which outputs require human sign-off. Malformed passports crash the server rather than serve bad data.

Inspectable via API
⚖️

Independent Verification

A separate verification agent checks every AI draft against the GAMP 5 regulatory corpus — criticality alignment, rationale relevance, contradiction scan. Non-compliant drafts are rejected and logged as compliance exceptions.

Rejections are audit events
🔗

Logic Archives

Every AI decision writes its full reasoning chain — inputs, steps, outputs — hash-linked (SHA-256) to a tamper-evident audit trail. An inspector can re-derive any decision from its inputs alone.

21 CFR Part 11 audit trail
✍️

Human Signature Gates

Phase completion, change control, release go-live — every irreversible step gates on a named human signature with a Manifestation of Signature page. The AI proposes; it never has the last word.

Enforced in the passport layer
The honesty contract

Five deployments we refuse. Regardless of revenue.

Reading this list is the fastest way to understand how EVOLV treats risk. These are structural exclusions — no amount of controls rescues them.

EX-1

AI executes an electronic signature

21 CFR Part 11 §11.50 binds a signature to a named human. An AI cannot be the named signatory.

EX-2

AI releases a batch or lot autonomously

Batch release is a Qualified Person responsibility under GMP. It cannot be delegated to an AI in any shape.

EX-3

AI closes a CAPA or deviation on its own

CAPA closure requires independent review and effectiveness assessment under 21 CFR §820.100.

EX-4

AI makes a clinical decision affecting a patient

That's FDA SaMD territory — a different product with a different regulatory pathway. Not ours.

EX-5

AI writes to a validated record without a human gate

Every modification to a controlled record carries an accountable signature — 21 CFR §11.10(e).

A vendor who never says no to your use case isn't assessing it. The exclusion rules run live in the screener above — try to get past them.

What lands on your desk

Inspection-ready artefacts, signed and versioned.

Validation PlanPhase-1 PDF, signed
URS / UR / FRwith regulatory rationale
Risk AssessmentsGAMP 5 + CSA matrices
Test Scriptsper-step citations
Design Specificationtraceability included
Validation SummaryPhase-6 closing PDF
Living Traceability MatrixUR → test → defect → release
Audit Trail Exportfiltered, signed, chained

"With every project you worked on, you went over and above what was asked for, and your attitude was always positive, bright, and inspiring."

— Director, IT CSV · on working with EVOLV's founder

"You were such an integral part of our successes. You made my job easier just knowing I had your support along the way."

— Sr Manager, GxP Global Quality Systems · on working with EVOLV's founder

"I built EVOLV because validation deserves better than choosing between speed and defensibility. Every design decision starts from one question: will this survive an inspector asking 'show me how the AI decided that'? If your QA team wants to try to break it, I'd genuinely love that meeting."

Sree
Founder, EVOLV — WingstarTech Inc. · LinkedIn · sreejith@evolifeval.com

See your first verified requirement in 15 minutes.

Bring one real requirement from your current validation backlog. We'll draft it, verify it, risk-rank it, and hand you the signed PDF — live.